Publications

According to Google Scholar, our publications have been cited more than 24,000 times with an H-index of 30.

Selected

Circular RNAs in the human brain are tailored to neuron identity and neuropsychiatric disease.
Circular RNAs in the human brain are tailored to neuron identity and neuropsychiatric disease.
Xianjun Dong, Yunfei Bai, Zhixiang Liao, David Gritsch, Xiaoli Liu, Tao Wang, Rebeca Borges-Monroy, Alyssa Ehrlich, Geidy E Serrano, Mel B Feany, Thomas G Beach, Clemens R Scherzer
Nature communications   ·   18 Sep 2023   ·   pubmed:37723137
Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease.
Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease.
Xianjun Dong, Zhixiang Liao, David Gritsch, Yavor Hadzhiev, Yunfei Bai, Joseph J Locascio, Boris Guennewig, Ganqiang Liu, Cornelis Blauwendraat, Tao Wang, Charles H Adler, John C Hedreen, Richard L M Faull, Matthew P Frosch, Peter T Nelson, Patrizia Rizzu, Antony A Cooper, Peter Heutink, Thomas G Beach, John S Mattick, Ferenc Müller, Clemens R Scherzer
Nature neuroscience   ·   17 Sep 2018   ·   pubmed:30224808
Exosome detection via the ultrafast-isolation system: EXODUS.
Exosome detection via the ultrafast-isolation system: EXODUS.
Yuchao Chen, Qingfu Zhu, Liming Cheng, Yong Wang, Meng Li, Qinsi Yang, Liang Hu, Doudou Lou, Jiaoyuan Li, Xianjun Dong, Luke P Lee, Fei Liu
Nature methods   ·   11 Jan 2021   ·   pubmed:33432243
Review of multi-omics data resources and integrative analysis for human brain disorders.
Review of multi-omics data resources and integrative analysis for human brain disorders.
Xianjun Dong, Chunyu Liu, Mikhail Dozmorov
Briefings in functional genomics   ·   17 Jul 2021   ·   pubmed:33969380
powerEQTL: an R package and shiny application for sample size and power calculation of bulk tissue and single-cell eQTL analysis.
powerEQTL: an R package and shiny application for sample size and power calculation of bulk tissue and single-cell eQTL analysis.
Xianjun Dong+, Xiaoqi Li, Tzuu-Wang Chang, Clemens R Scherzer, Scott T Weiss, Weiliang Qiu+
Bioinformatics   ·   18 Nov 2021   ·   pubmed:34009297
An integrated encyclopedia of DNA elements in the human genome.
An integrated encyclopedia of DNA elements in the human genome.
ENCODE Consortium
Nature   ·   06 Sep 2012   ·   pubmed:22955616
Exonic remnants of whole-genome duplication reveal cis-regulatory function of coding exons.
Exonic remnants of whole-genome duplication reveal cis-regulatory function of coding exons.
Xianjun Dong, Pavla Navratilova, David Fredman, Øyvind Drivenes, Thomas S Becker, Boris Lenhard
Nucleic acids research   ·   06 Dec 2009   ·   pubmed:19969543
We for the first time identified a set of human exons that can have both functions of coding protein and being enhancers.

All

2023

FLED: a full-length eccDNA detector for long-reads sequencing data
Fuyu Li, Wenlong Ming, Wenxiang Lu, Ying Wang, Xiaohan Li, Xianjun Dong+, Yunfei Bai+
Briefings in bioinformatics   ·   22 Sep 2023   ·   pubmed:37930031
Circular RNAs in the human brain are tailored to neuron identity and neuropsychiatric disease.
Xianjun Dong, Yunfei Bai, Zhixiang Liao, David Gritsch, Xiaoli Liu, Tao Wang, Rebeca Borges-Monroy, Alyssa Ehrlich, Geidy E Serrano, Mel B Feany, Thomas G Beach, Clemens R Scherzer
Nature communications   ·   18 Sep 2023   ·   pubmed:37723137
Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci.
Xikun Han, Puya Gharahkhani, Andrew R Hamel, Jue Sheng Ong, Miguel E Rentería, Puja Mehta, Xianjun Dong, Francesca Pasutto, Christopher Hammond, Terri L Young, Pirro Hysi, Andrew J Lotery, Eric Jorgenson, Hélène Choquet, Michael Hauser, Jessica N Cooke Bailey, Toru Nakazawa, Masato Akiyama, Yukihiro Shiga, Zachary L Fuller, Xin Wang, Alex W Hewitt, Jamie E Craig, Louis R Pasquale, David A Mackey, Janey L Wiggs, Anthony P Khawaja, Ayellet V Segrè, Stuart MacGregor
Nature genetics   ·   29 Jun 2023   ·   pubmed:37386247
Discovery of genomic loci associated with sleep apnea risk through multi-trait GWAS analysis with snoring.
Adrian I Campos, Nathan Ingold, Yunru Huang, Brittany L Mitchell, Pik-Fang Kho, Xikun Han, Luis M García-Marín, Jue-Sheng Ong, Matthew H Law, Jennifer S Yokoyama, Nicholas G Martin, Xianjun Dong, Gabriel Cuellar-Partida, Stuart MacGregor, Stella Aslibekyan, Miguel E Rentería
Sleep   ·   09 Mar 2023   ·   pubmed:36525587

2022

WebCSEA: web-based cell-type-specific enrichment analysis of genes.
Yulin Dai, Ruifeng Hu, Andi Liu, Kyung Serk Cho, Astrid Marilyn Manuel, Xiaoyang Li, Xianjun Dong, Peilin Jia, Zhongming Zhao
Nucleic acids research   ·   05 Jul 2022   ·   pubmed:35610053
The Parkinson's disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability.
Erinc Hallacli, Can Kayatekin, Sumaiya Nazeen, Xiou H Wang, Zoe Sheinkopf, Shubhangi Sathyakumar, Souvarish Sarkar, Xin Jiang, Xianjun Dong, Roberto Di Maio, Wen Wang, Matthew T Keeney, Daniel Felsky, Jackson Sandoe, Aazam Vahdatshoar, Namrata D Udeshi, D R Mani, Steven A Carr, Susan Lindquist, Philip L De Jager, David P Bartel, Chad L Myers, J Timothy Greenamyre, Mel B Feany, Shamil R Sunyaev, Chee Yeun Chung, Vikram Khurana
Cell   ·   09 Jun 2022   ·   pubmed:35688132
Genome-wide association meta-analysis identifies 29 new acne susceptibility loci.
Brittany L Mitchell, Jake R Saklatvala, Nick Dand, Fiona A Hagenbeek, Xin Li, Josine L Min, Laurent Thomas, Meike Bartels, Jouke Jan Hottenga, Michelle K Lupton, Dorret I Boomsma, Xianjun Dong, Kristian Hveem, Mari Løset, Nicholas G Martin, Jonathan N Barker, Jiali Han, Catherine H Smith, Miguel E Rentería, Michael A Simpson
Nature communications   ·   07 Feb 2022   ·   pubmed:35132056

2021

powerEQTL: an R package and shiny application for sample size and power calculation of bulk tissue and single-cell eQTL analysis.
Xianjun Dong+, Xiaoqi Li, Tzuu-Wang Chang, Clemens R Scherzer, Scott T Weiss, Weiliang Qiu+
Bioinformatics   ·   18 Nov 2021   ·   pubmed:34009297
The genetic source tracking of human urinary exosomes.
Qingfu Zhu, Liming Cheng, Chunyu Deng, Liu Huang, Jiaoyuan Li, Yong Wang, Meng Li, Qinsi Yang, Xianjun Dong, Jianzhong Su, Luke P Lee, Fei Liu
PNAS   ·   26 Oct 2021   ·   pubmed:34663731
A pipeline for RNA-seq based eQTL analysis with automated quality control procedures.
Tao Wang, Yongzhuang Liu, Junpeng Ruan, Xianjun Dong, Yadong Wang, Jiajie Peng
BMC bioinformatics   ·   25 Aug 2021   ·   pubmed:34433407
Review of multi-omics data resources and integrative analysis for human brain disorders.
Xianjun Dong, Chunyu Liu, Mikhail Dozmorov
Briefings in functional genomics   ·   17 Jul 2021   ·   pubmed:33969380
Understanding the effect of smoking and drinking behavior on Parkinson's disease risk: a Mendelian randomization study.
Carmen Domínguez-Baleón, Jue-Sheng Ong, Clemens R Scherzer, Miguel E Rentería, Xianjun Dong+
Scientific reports   ·   07 Jul 2021   ·   pubmed:34234189
Accelerating Medicines Partnership: Parkinson's Disease. Genetic Resource.
Hirotaka Iwaki, Hampton L Leonard, Mary B Makarious, Matt Bookman, Barry Landin, David Vismer, Bradford Casey, J Raphael Gibbs, Dena G Hernandez, Cornelis Blauwendraat, Daniel Vitale, Yeajin Song, Dinesh Kumar, Clifton L Dalgard, Mahdiar Sadeghi, Xianjun Dong, Leonie Misquitta, Sonja W Scholz, Clemens R Scherzer, Mike A Nalls, Shameek Biswas, Andrew B Singleton
Movement disorders   ·   07 May 2021   ·   pubmed:33960523
Genome-wide survival study identifies a novel synaptic locus and polygenic score for cognitive progression in Parkinson's disease.
Ganqiang Liu, Jiajie Peng, Zhixiang Liao, Joseph J Locascio, Jean-Christophe Corvol, Frank Zhu, Xianjun Dong, Jodi Maple-Grødem, Meghan C Campbell, Alexis Elbaz, Suzanne Lesage, Alexis Brice, Graziella Mangone, John H Growdon, Albert Y Hung, Michael A Schwarzschild, Michael T Hayes, Anne-Marie Wills, Todd M Herrington, Bernard Ravina, Ira Shoulson, Pille Taba, Sulev Kõks, Thomas G Beach, Florence Cormier-Dequaire, Guido Alves, Ole-Bjørn Tysnes, Joel S Perlmutter, Peter Heutink, Sami S Amr, Jacobus J van Hilten, Meike Kasten, Brit Mollenhauer, Claudia Trenkwalder, Christine Klein, Roger A Barker, Caroline H Williams-Gray, Johan Marinus, Clemens R Scherzer
Nature genetics   ·   06 May 2021   ·   pubmed:33958783
Genetic Modifiers of Age at Onset for Parkinson's Disease in Asians: A Genome-Wide Association Study.
Chunyu Li, Ruwei Ou, Yongping Chen, Xiaojing Gu, Qianqian Wei, Bei Cao, Lingyu Zhang, Yanbing Hou, Kuncheng Liu, Xueping Chen, Wei Song, Bi Zhao, Ying Wu, Tao Li, Xianjun Dong, Huifang Shang
Movement disorders   ·   21 Apr 2021   ·   pubmed:33884653
Exosome detection via the ultrafast-isolation system: EXODUS.
Yuchao Chen, Qingfu Zhu, Liming Cheng, Yong Wang, Meng Li, Qinsi Yang, Liang Hu, Doudou Lou, Jiaoyuan Li, Xianjun Dong, Luke P Lee, Fei Liu
Nature methods   ·   11 Jan 2021   ·   pubmed:33432243

2020

High-resolution analysis of differential gene expression during skeletal muscle atrophy and programmed cell death.
Junko Tsuji, Travis Thomson, Elizabeth Chan, Christine K Brown, Julia Oppenheimer, Carol Bigelow, Xianjun Dong, William E Theurkauf, Zhiping Weng, Lawrence M Schwartz
Physiological genomics   ·   14 Sep 2020   ·   pubmed:32926651

2019

Publisher Correction: Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease.
Xianjun Dong, Zhixiang Liao, David Gritsch, Yavor Hadzhiev, Yunfei Bai, Joseph J Locascio, Boris Guennewig, Ganqiang Liu, Cornelis Blauwendraat, Tao Wang, Charles H Adler, John C Hedreen, Richard L M Faull, Matthew P Frosch, Peter T Nelson, Patrizia Rizzu, Antony A Cooper, Peter Heutink, Thomas G Beach, John S Mattick, Ferenc Müller, Clemens R Scherzer
Nature neuroscience   ·   01 Jan 2019   ·   pubmed:30482917

2018

Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease.
Xianjun Dong, Zhixiang Liao, David Gritsch, Yavor Hadzhiev, Yunfei Bai, Joseph J Locascio, Boris Guennewig, Ganqiang Liu, Cornelis Blauwendraat, Tao Wang, Charles H Adler, John C Hedreen, Richard L M Faull, Matthew P Frosch, Peter T Nelson, Patrizia Rizzu, Antony A Cooper, Peter Heutink, Thomas G Beach, John S Mattick, Ferenc Müller, Clemens R Scherzer
Nature neuroscience   ·   17 Sep 2018   ·   pubmed:30224808

2017

β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson's disease.
Shuchi Mittal, Kjetil Bjørnevik, Doo Soon Im, Adrian Flierl, Xianjun Dong, Joseph J Locascio, Kristine M Abo, Elizabeth Long, Ming Jin, Bing Xu, Yang K Xiang, Jean-Christophe Rochet, Anders Engeland, Patrizia Rizzu, Peter Heutink, Tim Bartels, Dennis J Selkoe, Barbara J Caldarone, Marcie A Glicksman, Vikram Khurana, Birgitt Schüle, David S Park, Trond Riise, Clemens R Scherzer
Science   ·   01 Sep 2017   ·   pubmed:28860381

2015

The Role of H3K4me3 in Transcriptional Regulation Is Altered in Huntington's Disease.
Xianjun Dong, Junko Tsuji, Adam Labadorf, Panos Roussos, Jiang-Fan Chen, Richard H Myers, Schahram Akbarian, Zhiping Weng
PloS One   ·   04 Dec 2015   ·   pubmed:26636336
Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson's disease.
Joseph J Locascio, Shirley Eberly, Zhixiang Liao, Ganqiang Liu, Ashley N Hoesing, Karen Duong, Ana Trisini-Lipsanopoulos, Kaltra Dhima, Albert Y Hung, Alice W Flaherty, Michael A Schwarzschild, Michael T Hayes, Anne-Marie Wills, U Shivraj Sohur, Nicte I Mejia, Dennis J Selkoe, David Oakes, Ira Shoulson, Xianjun Dong, Ken Marek, Bin Zheng, Adrian Ivinson, Bradley T Hyman, John H Growdon, Lewis R Sudarsky, Michael G Schlossmacher, Bernard Ravina, Clemens R Scherzer
Brain   ·   28 Jul 2015   ·   pubmed:26220939

2014

Epigenetic dysregulation of hairy and enhancer of split 4 (HES4) is associated with striatal degeneration in postmortem Huntington brains.
Guang Bai, Iris Cheung, Hennady P Shulha, Joana E Coelho, Ping Li, Xianjun Dong, Mira Jakovcevski, Yumei Wang, Anastasia Grigorenko, Yan Jiang, Andrew Hoss, Krupal Patel, Ming Zheng, Evgeny Rogaev, Richard H Myers, Zhiping Weng, Schahram Akbarian, Jiang-Fan Chen
Human molecular genetics   ·   05 Dec 2014   ·   pubmed:25480889
MicroRNAs located in the Hox gene clusters are implicated in huntington's disease pathogenesis.
Andrew G Hoss, Vinay K Kartha, Xianjun Dong, Jeanne C Latourelle, Alexandra Dumitriu, Tiffany C Hadzi, Marcy E Macdonald, James F Gusella, Schahram Akbarian, Jiang-Fan Chen, Zhiping Weng, Richard H Myers
PLoS genetics   ·   27 Feb 2014   ·   pubmed:24586208
Two independent transcription initiation codes overlap on vertebrate core promoters.
Vanja Haberle, Nan Li, Yavor Hadzhiev, Charles Plessy, Christopher Previti, Chirag Nepal, Jochen Gehrig, Xianjun Dong, Altuna Akalin, Ana Maria Suzuki, Wilfred F J van IJcken, Olivier Armant, Marco Ferg, Uwe Strähle, Piero Carninci, Ferenc Müller, Boris Lenhard
Nature   ·   16 Feb 2014   ·   pubmed:24531765

2013

The correlation between histone modifications and gene expression.
Xianjun Dong, Zhiping Weng
Epigenomics   ·   01 Apr 2013   ·   pubmed:23566087
An ancient transcription factor initiates the burst of piRNA production during early meiosis in mouse testes.
Xin Zhiguo Li, Christian K Roy, Xianjun Dong, Ewelina Bolcun-Filas, Jie Wang, Bo W Han, Jia Xu, Melissa J Moore, John C Schimenti, Zhiping Weng, Phillip D Zamore
Molecular cell   ·   21 Mar 2013   ·   pubmed:23523368

2012

Factorbook.org: a Wiki-based database for transcription factor-binding data generated by the ENCODE consortium.
Jie Wang, Jiali Zhuang, Sowmya Iyer, Xin-Ying Lin, Melissa C Greven, Bong-Hyun Kim, Jill Moore, Brian G Pierce, Xianjun Dong, Daniel Virgil, Ewan Birney, Jui-Hung Hung, Zhiping Weng
Nucleic acids research   ·   29 Nov 2012   ·   pubmed:23203885
An integrated encyclopedia of DNA elements in the human genome.
ENCODE Consortium
Nature   ·   06 Sep 2012   ·   pubmed:22955616
Understanding transcriptional regulation by integrative analysis of transcription factor binding data.
Chao Cheng, Roger Alexander, Renqiang Min, Jing Leng, Kevin Y Yip, Joel Rozowsky, Koon-Kiu Yan, Xianjun Dong, Sarah Djebali, Yijun Ruan, Carrie A Davis, Piero Carninci, Timo Lassman, Thomas R Gingeras, Roderic Guigó, Ewan Birney, Zhiping Weng, Michael Snyder, Mark Gerstein
Genome research   ·   01 Sep 2012   ·   pubmed:22955978
Sequence features and chromatin structure around the genomic regions bound by 119 human transcription factors.
Jie Wang, Jiali Zhuang, Sowmya Iyer, XinYing Lin, Troy W Whitfield, Melissa C Greven, Brian G Pierce, Xianjun Dong, Anshul Kundaje, Yong Cheng, Oliver J Rando, Ewan Birney, Richard M Myers, William S Noble, Michael Snyder, Zhiping Weng
Genome research   ·   01 Sep 2012   ·   pubmed:22955990
Modeling gene expression using chromatin features in various cellular contexts.
Xianjun Dong, Melissa C Greven, Anshul Kundaje, Sarah Djebali, James B Brown, Chao Cheng, Thomas R Gingeras, Mark Gerstein, Roderic Guigó, Ewan Birney, Zhiping Weng
Genome biology   ·   13 Jun 2012   ·   pubmed:22950368

2011

Making enhancers from spare parts of the genome.
David Fredman, Xianjun Dong, Boris Lenhard
Genome biology   ·   29 Dec 2011   ·   pubmed:22206586
Mbd3/NURD complex regulates expression of 5-hydroxymethylcytosine marked genes in embryonic stem cells.
Ozlem Yildirim, Ruowang Li, Jui-Hung Hung, Poshen B Chen, Xianjun Dong, Ly-Sha Ee, Zhiping Weng, Oliver J Rando, Thomas G Fazzio
Cell   ·   23 Dec 2011   ·   pubmed:22196727
A user's guide to the encyclopedia of DNA elements (ENCODE)
PLoS biology   ·   19 Apr 2011   ·   pubmed:21526222

2010

Translog, a web browser for studying the expression divergence of homologous genes.
Xianjun Dong, Altuna Akalin, Yogita Sharma, Boris Lenhard
BMC bioinformatics   ·   18 Jan 2010   ·   pubmed:20122234

2009

Exonic remnants of whole-genome duplication reveal cis-regulatory function of coding exons.
Xianjun Dong, Pavla Navratilova, David Fredman, Øyvind Drivenes, Thomas S Becker, Boris Lenhard
Nucleic acids research   ·   06 Dec 2009   ·   pubmed:19969543
We for the first time identified a set of human exons that can have both functions of coding protein and being enhancers.
Synorth: exploring the evolution of synteny and long-range regulatory interactions in vertebrate genomes.
Xianjun Dong, David Fredman, Boris Lenhard
Genome biology   ·   21 Aug 2009   ·   pubmed:19698106
Transcriptional features of genomic regulatory blocks.
Altuna Akalin, David Fredman, Erik Arner, Xianjun Dong, Jan Christian Bryne, Harukazu Suzuki, Carsten O Daub, Yoshihide Hayashizaki, Boris Lenhard
Genome biology   ·   19 Apr 2009   ·   pubmed:19374772
The brainstorm
Xianjun Dong
IEEE Potentials   ·   01 Jan 2009   ·   doi:10.1109/mpot.2008.931159

2008

Differential evolution of the 13 Atlantic salmon Hox clusters.
Sutada Mungpakdee, Hee-Chan Seo, Anna Rita Angotzi, Xianjun Dong, Altuna Akalin, Daniel Chourrout
Molecular biology and evolution   ·   18 Apr 2008   ·   pubmed:18424774

2007

gWord: A Tool for Genome-Wide Word Search and Count
Jianming Xie, Xiao Sun, Zhiyuan Lu, Weiyan Xue, Xianjun Dong, Zuhong Lu
2007 1st International Conference on Bioinformatics and Biomedical Engineering   ·   01 Jul 2007   ·   doi:10.1109/ICBBE.2007.84