WHERE COMPUTER GEEKS HAVE A CRUSH ON THE HUMAN GENOME
The Dong Lab is a team of researchers at Brigham and Women’s Hospital and Harvard Medical School dedicated to answering important questions in genome biology and brain diseases with computation. We focus on studying transcriptional regulation and non-coding RNAs and their roles in neurodegenerative diseases through developing computational methods to integrate and analyze multi-omics and clinical data.
Highlights
Our Research
We study (1) transcriptional regulation, incl. discovery of regulatory elements in the human genome and how they contribute to gene expression; (2) non-coding RNAs (such as eRNA, circRNA, piRNA, miRNA) and their role in neurological diseases; and (3) AI in precision medicine by integrating multi-model data (e.g. omics, clinical, imaging, and wearable device) and the latest machine learning methods to predict disease diagnosis and progression.
Our Projects
We live on collaboration. In most time, we talk to the front-end doctors or biologists and understand their questions. We use public-available datasets or generate our own data. We develop computational methods or tools to solve the problem (hopefully) and very often we enjoy the fun of new discovery together.
Our Team
We are a team of enthusiastic researchers that enjoy the marriage of genome research and data science. We strive to build a learning environment for interdisciplinary research, and recognize the value of diversity in the process of discovery.
News
Congratulations to Dr. Jie Yuan that his abstract entitled “The Parkinson’s Cell Atlas: A spatial map of disease programs in human brains” has been selected for a platform oral presentation at the 2023 American Society of Human Genetics (ASHG) Annual Meeting in Washington, DC, from November 1-5! (8/2/2023)
Welcome Yuxuan Hu from China Pharmaceutical University joining the lab as a visiting student! (10/18/2023)
Welcome Dr. Mingming Lu joining the lab as a postdoc reserach fellow! (1/16/2024)
Congratulations to Rosan Wang for receiving a PhD offer from UMass Medical School! (2/3/2024)
Congratulations to Rosan Wang that her work about “Identifying enhancer RNAs in blood and their immunological role for Parkinson’s disease” was invited by FNIH to present at the Inaugural Accelerating Medicines Partnership® (AMP®) Program Symposium in Bethesda, Maryland, celebrating the AMP program’s 10th anniversary. Dr Dong will present the work on behalf of the team! (2/5/2024)
Congratulations to Lucy Tian for receiving an offer from USC’s Computational Biology PhD program! (2/13/2024)
Congratulations to Rosan Wang and Lucy Tian for receiving offers from UCSD’s Bioinformatics and Systems Biology PhD program! (2/27/2024)
Congratulations to Lucy Tian for receiving a PhD offer from Cornell University! (2/28/2024)